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Overall, available evidence suggests that ferroptosis may contribute to skeletal muscle atrophy across diverse pathological contexts, including CKD, chemotherapy, sepsis and inflammatory states

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C., Sellge, G., Schwengberg, S., Lorentz, A

This predicted increase in the older human population will increase the need for healthcare and will intensify the stress on healthcare systems around the world

The nuclear transcription factor paired box 2 (Pax2), crucial for renal cell proliferation regulation, is overexpressed due to decreased CMA activity, promoting tubular epithelial cell growth and maintaining the hypertrophic state (211)