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Sleep Support Methylcobalamin has been reported to affect the primary circadian rhythm associated with sleep.[8,10] Research supports a role for methylcobalamin supplementation in modulating melatonin secretion, enhancing light-sensitivity, normalizing circadian rhythms, and improving sleep-wake cycles.*[11-13]

Nat Rev Endocrinol

2 B12 deficiency can be due to inadequate dietary intake, in particular in people following a strict vegan diet (B12 is only found in animal foods)

(October 29, 2008)

Comment: Many commenters offered recommendations to CMS on additional topped out measures that CMS should include in the proposed list of topped out measures that would be subject to the topped out measure benchmark