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Folinic acid can cross the blood-brain barrier using the reduced folate carrier (RFC) when the FR is blocked by FRAAs or non-functional due to mitochondrial dysfunction and/or genetic mutations

Rutledge took acetaminophen throughout both pregnancies

For multi-arm or longitudinal studies, researchers can correlate batch-specific variation with endpoint variation, something that is awkward to reconcile when reconstituting from unlabelled lyophilised vials across multiple sessions, where each reconstitution introduces fresh variables

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Anything less than 200 pg/ml is generally considered to be a deficiency

doi: 10.1053/j.gastro.2009.12.054 Summary Keywords immunometabolism, Th17/Treg balance, autoimmune diseases, therapeutic target, mTOR Citation Hu Y, Zhao Q, Dai H, Wu Y, Tang X, Zhang N, Jiang H, Rui H and Liu B (2025) Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review