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Schmidt DR, Patel R, Kirsch DG, Lewis CA, Vander Heiden MG, Locasale JW

In addition to these features, the N-terminal also contains nucleotide recognition lids and a loop structure, which contribute to substrate selectivity 125

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Thus, the developmental stage of tumor vasculature is critical to anti-VEGF therapy sensitivity and the lack of good in vitro resistance models has slowed the development of non-VEGF anti-angiogenic therapies

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