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Its transport to mitochondria results in cell apoptosis via mitochondrial transmembrane potential (m) dissipation, cytochrome c release, and Bcl-2 - associated X protein (Bax) activation [93]

4d,e and Extended Data Fig

By the time you're 30, your levels have already started dropping, and by 60, they can be reduced by up to 50%

Inhibition of NRF2 in cancer cells has been reported to suppress HIF activity through multiple molecular events, including direct regulation of HIF-1 expression by NRF2, HIF-1 stabilization by the NRF2 target NQO1 and TRX1, and HO-1-driven CO and miRNA expression 58,59,61,65,66