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However, most of the drugs mentioned in the article (such as andrographolide, rapamycin, azathioprine, JAK inhibitors, etc.) have shown potential in mechanistic studies, but their clinical translation faces three major obstacles: imprecise targeting, safety concerns, and difficulty in preventing drug resistance. Some drugs lack cell or tissue specificity, such as insufficient local drug concentration in the intestine, and are prone to systemic side effects

10.3233/NRE-130873 97 RineR

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Note the reduced ratio of GSH:GSSG between those with autism and the NT controls Iron has a major role in the conversion of energy generated from the metabolism of fats, sugar and protein, and as iron levels drop (as measured by serum ferritin), the energy conversion via the iron-sulpur enzyme aconitase drops rapidly and there is an increased excretion of citrate in urine - representing metabolic energy that cannot be processed