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Eltayeb AE, Yamamoto S, Habora MEE, Yin L, Tsujimoto H, Tanaka K

Cyclophosphamide is an antineoplastic, broad-spectrum anti-tumor and anti-cancer alkylating agent and is also used as an immunosuppressant for treatment of autoimmune diseases and in bone marrow transplants [8]

The insert of construct pAGB676 (contains hrcL to hrcT and hrcC with a deletion) was subsequently assembled with the insert of pAGB197 (contains hrpB1 to hrpB4 ) in the Bpi I sites of vector pICH41331, resulting in the level 0 construct pAGB680

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Lin et al., 2014)

DKD patients exhibit significant structural dysbiosis of gut microbiota, characterized by decreased abundance of beneficial bacteria producing short-chain fatty acids (SCFAs) and increased abundance of harmful bacteria generating uremic toxin precursors (12)