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Mechanistic investigations further revealed that RvD2 exerts its effects by binding to the GPR18, which inhibits ERK1/2iNOS signaling and mitigates both inflammation and oxidative stress [175]

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have also proposed objective criteria for COVID-19 hyper-inflammatory syndrome (cHIS) based on fever, hematological dysfunction, macrophage activation, liver involvement, coagulation abnormalities and hypercytokinemia [94]