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Ali A, Esmaeil A, Behbehani R (2024) Mitochondrial chronic progressive external ophthalmoplegia

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Nat Metab (2019) 1(11):10518

Redesign of a four-helix bundle protein by phage display coupled with proteolysis and structural characterization by NMR and X-ray crystallography

It participates in the transport of fatty acids to the mitochondrion and in the balance of acyls, so it is studied in energy metabolism and recovery

The observation in RCC aligns with our findings showing that HIF2 KO NSCLC cells are dependent on -KG synthesis, which is facilitated by PHGDH and phosphoserine aminotransferase 1 (PSAT1) reactions, and consequently indicates that these cells are specifically sensitive to PHGDH inhibitors rather than to downstream targeting of SHMT by sertraline