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Likewise, another study using chloroquine, an autophagy inhibitor, in combination with 5-FU showed an enhanced anti-proliferative effect of 5-FU in CRC cells (144)

doi: 10.1254/JPHS.FP0070136 53 JayarajR

Similarly, a phase I study of JNJ-63898081 (JNJ-081), a PSMA-targeted agent, explored intravenous (0.33.0 g/kg) and subcutaneous (3.060 g/kg) administration in 39 mCRPC patients

Data availability Accession numbers for the genes mentioned in this article are: UgsL (Uv8b_2091)

The strongest effects were observed for Put at concentrations of 1 mM and 2.5 mM and ChPut at the 2.5 mM concentration, suggesting the potential use of these substances in strategies to increase plant tolerance to chilling stress