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PMID: 46 LyuFLongWMaL

Thain A, Hart K, Ahmadi KR European journal of clinical nutrition 2025

However, examination of the correlation between BMI and MTHFR genotypes according to sex revealed that in diabetic women, the wild-type genotype (CC) elevated BMI independently of lipids ( p = 0.009)

SOHO 2014, 2014

Nature 460 (7257), 831838

Standard dosing protocols Beginner dose (first 2-3 uses): 1mg (1000mcg) per dose Single spray per nostril (0.5mg each) OR full 1mg in one nostril 30-60 minutes before anticipated sexual activity Assess tolerance and effectiveness Standard dose (most men): 1.5mg (1500mcg) per dose Effective for 70-80% of men 45-60 minutes before sex Use 1-2 times weekly maximum Maximum dose: 2mg (2000mcg) per dose Only if 1-1.5mg insufficient Do NOT exceed 2mg Higher doses = more side effects, not necessarily better results Frequency limits: Maximum 2-3 doses per week Allow 48-72 hours between doses Don't use daily (tolerance and side effects) How to administer PT-141 nasal spray Step-by-step administration: Prepare spray: Remove cap from nasal spray bottle If first use, prime by spraying once into air Hold upright Position: Tilt head slightly forward (NOT back) Close one nostril with finger Insert spray tip into open nostril Spray: Spray once while inhaling gently through nose Remove spray tip Breathe gently through nose to distribute Repeat if needed: Switch nostrils for second spray if dosing 1mg+ total Don't spray more than recommended dose After administration: Avoid blowing nose for 15-30 minutes Sit or stand for a few minutes Wait 30-60 minutes before sexual activity Storage: Refrigerate nasal spray (2-8C) Protect from light Use within 30 days of opening Check expiration date See our peptide storage guide for detailed storage info