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Hepatocyte growth factor-induced c-MET activation leads to increased membrane ruffling, filopodia formation, and also motility/migration in SCLC (Maulik et al, 2002a)

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This results in the dilation (widening) of blood vessels, which lowers blood pressure

This subsequently impedes tumorigenicity and invasiveness while enhancing chemosensitivity in PDAC, particularly in CD133 + CSCs [76, 86]

And they dont stay upside down for very long, but they justthey repeatedly are upside down quite a bit

For instance, dietary restriction has been shown to extend lifespan and delay the onset of multiple age-related pathologies across various organisms (Chmielewski et al, 2024