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[6] [42] [43] For single doses of lipophilic, multi-compartment drugs, clinical duration after onset is often driven by the distribution () phase, because by the time distribution equilibrium is reached plasma levels are frequently below any minimal effective concentration, so the terminal phase has little bearing on observable effects

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For combination protocols, published curves show the cagrilintide-plus-semaglutide arm pulling ahead of either single agent during this period (Frias et al., 2023)