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Under resting conditions, the NMDAR channel pores are blocked by Mg 2+ ions and once sufficient membrane depolarization has been established, the Mg 2+ block is removed, allowing the influx of cations (Lin et al., 2008

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In the experimental models, constitutive autophagy in neurons maintains cellular homeostasis by balancing protein synthesis and degradation, particularly within the distal axonal processes [225, 226]