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One way in which Htt aggregates could cause toxicity is through depleting ubiquitin, a protein that binds to misfolded proteins to promote their clearance through the ubiquitin-proteasome system ( Notably, the N-terminal 17-residue domain stretch of huntingtin folds into an amphipathic -helix in the presence of membranes (Pandey et al., 2018)

Relapse and disease persistence after allo-HSCT resulting in treatment failure and death is another significant challenge in addition to the transplant-related toxicity

Nat Commun 5: 4846

On the contrary, in female offspring the changes in Pon1 and Pon3 mRNA levels were not statistically significant

Coates, J

sample solution concentrations, the IC 50 values (M) were determined