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It neutralizes free radicals and reactive oxygen species (ROS), preventing oxidative stress and cellular damage

Intranasal delivery of iron chelators and management of central nervous system disease

Many studies have shown that a deficit in glutathione is associated with psychopathology and clinical variables in schi-zophrenia.100101102 Mitochondrial dysfunction, which is closely associated with oxidative stress, is also associated with neurodegenerative change in schizophrenia

For example, a clinical cohort study from NHANES 20172018 showed an inverse relationship between plasma vitamin C levels and high-sensitivity CRP (hs-CRP), a key marker of inflammation, with the most significant CRP reduction observed at plasma vitamin C levels up to 53.1 mol/L [59]

The activity of these effectors is essential for the development and maintenance of this replicative niche[4]

The hyperphosphorylation of Tau and the aggregation of A can occur from this activation