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Second, the execution core of ferroptosis involves the peroxidation of polyunsaturated fatty acid-containing phospholipids(PUFA-PLs) in membrane lipids, leading to the massive accumulation of cytotoxic lipid peroxidation derivatives such as specific lipid hydroperoxides and reactive aldehydes like 4-hydroxynonenal(4-HNE), ultimately causing irreversible damage to plasma membrane integrity (Guo et al., 2024)

Nutrients 11(7):1624

S2CID 4984228

Regina Castro, M.D., GLP-1 agonists: Diabetes drugs and weight loss, Mayo Clinic

Figure 4.5 Characteristics of Inflammation in COPD and Asthma Since inflammation is a feature of COPD, it follows that anti-inflammatory therapies may have clinical benefit in controlling symptoms, preventing exacerbations, and slowing the progression of the disease

In addition, NGR1 inhibited the increase of LDH, AST, and CK-MB in the serum of diabetic mice