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Intrathecal administration of low doses significantly mitigated allodynia caused by sciatic nerve ligation, while high doses provided prolonged antinociceptive effects (454)

Cp1D and Cp2D do not have any sequence similarity to characterized bacterial ABSs such as McbA 32,36 , DdaF 40 , CfaL 34 and CysC 37 and can, therefore, be grouped into a distinct family of ABSs that activate N -acyl amino acids and dipeptides instead of simple organic acids by the bacterial ABSs (Fig

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Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction

This may lead to overall network activity interruption through cumulative effects, especially abnormal synchronous oscillations such as gamma rhythms