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The following equation was used to calculate the cooperativity of L-malate: where v denotes the initial velocity, V max denotes the reactions maximum rate, K 0.5 denotes the substrate concentration at half-maximal velocity, and h denotes the hill coefficient, which signifies the degree of cooperativity

[DOI] [PMC free article] [PubMed] [Google Scholar] 342.Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, Zweckstetter M, Masliah E, and Lashuel HA

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