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Another theory is that iron can enhance the ROS toxicity derived from DOX by forming anthracycline-iron complexes, converting relatively harmless substances into more reactive and toxic hydroxyl radicals (OH) or iron-peroxide complexes [238]

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Horiguchi H, Yurimoto H, Goh T-K et al (2001) Peroxisomal catalase in the methylotrophic yeast Candida boidinii : transport efficiency and metabolic significance