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Cortisol is a stress hormone that, when chronically elevated, promotes fat storage (particularly visceral fat), breaks down muscle tissue, impairs sleep, and suppresses immune function

This colonization directly induces local inflammation in blood vessels and disrupts lipid profiles, thus contributing to the progression of atherosclerosis 123

However, integrating metabolomics from strains grown with abundant nutrient source, shows that the AGAu group have significantly more active production of polyamine and choline metabolites, which requires the use of amino acid metabolism for production (Fig

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The ferroptosis inhibitors, such as deferoxamine (DFO), ferrostatin-1 (Fer-1), UAMC-3203, and vitamin E, exert a protective effect against this type of hepatocyte injury (Schnellmann et al., 1999

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