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Increasing evidence suggests that this axis exerts a profound influence on key neurobiological processes, including neuroinflammation, BBB permeability, neurotransmission, and synaptic plasticity, all of which are directly relevant to neurodegeneration and neuroprotection [615, 616]

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The RCTs reviewed in the meta-analyses included in this work were routinely reported as having significant heterogeneity, low to moderate methodologies, and high risk of bias, including poor blinding of investigators and subjects, analytical methods, and poor control of confounding factors

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They are thus considered attractive medicinal targets for the metabolic and aging-related diseases 9

Quantitative videographic analysis of blinking in normal subjects and patients with dry eye