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Significant downregulation of the branchial expression of Na + /K + ATPase -3 subunit (0.17-fold), calcium/calmodulin-dependant protein kinase 1 (0.23 fold), chloride channel protein 2 (0.38-fold), solute carrier family 12 a 2 (0.33-fold), and solute carrier family 4 a 4 (0.21-fold) was in the fish-reared under carbonate alkalinity stress

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This in vitro analysis manifested the upregulation of IB expression, resulting in the inhibition of NF-B pathway, hence providing anti-inflammatory effects (Wang Fang et al., 2016)

Lund et al., 2009

3,7 Hormonal influences oestrogen and progesterone may be implicated in the development of melasma, particularly given the increased prevalence of melasma during pregnancy, with the use of oral contraceptive agents containing oestrogen and progesterone, menopausal hormone therapy, intrauterine devices and implants

and Cluster-4 with fatigue (94%), PEM (94%), dizziness (94%), brain fog (94%), GI (88%), and palpitations (86%) 129