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It is important to optimize this step for good results

[PubMed] [Google Scholar] 9.Hyperpigmentation of skin

platensis F&M-C256 protein is higher than the 18% decrease observed (Table 4)

HIF-1 is also hydroxylated at the asparagine-803 residue (at Asn851) under the normoxic condition by the factor inhibiting HIF-1 (FIH-1), another O 2 -dependent dioxygenase requiring Fe 2+ and ascorbate as cofactors, which blocks the transcriptional activities of HIF-1 through disruption of its interaction with CBP/p300 [19,20,21]