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Concordant with this hypothesis, we observed that IFN- was important in SerpinB2 reduction in obesity, and the anti-apoptotic role of SerpinB2 has been demonstrated in inflammatory disease pathologies 137,138,139,140,141,142,143,144,145,146

Data and materials availability The raw sequencing data generated in this study have been deposited in the NCBI Sequence Read Archive (SRA) under the BioProject accession number PRJNA1345061.All LC-MS raw data for metabolomics have been uploaded to the Metabolomics Workbench ( with the project ID ST003920 ( All other data are available in the manuscript or supplementary materials

This reactive metabolite produces conjugation adducts for many cellular proteins, including those involved in the mitochondrial ETC and others [110, 268, 269]

doi: 10.1039/C3FO60400D

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The gene was subcloned into the BacMam vector 60 , with a C-terminal eGFP and PreScission cleavage site, using primers (Fwd: CCACTCCCAGTTCAATTACAGCTCTTAAGGGCCACCATGCGGGACTACGACGAGG and Rev: CAGCACTTCCAATCTAGATTCGAAAGCGGCGCCGAAGGCTGTGCTTTTAAGGATT