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No proprietary software was used in the data analysis

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5.3.2 Transcriptomics applications in CF Transcriptome profiling is a valuable tool in CF when studying the pathophysiology of the disease or when looking for new therapeutical targets (McKiernan et al., 2014

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Cisplatin (Table 1), the first metal-based drug used in the treatment of cancer, exerts its antiproliferative effects primarily by binding to DNA, blocking DNA replication and transcription, and triggering caspase activation and apoptosis [2,4,23]