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Nat Genet 46: 352356, 2014

Herzenberg, L

Dp71f and Dp71d isoforms bind in vitro to the nuclear envelope proteins lamin B1 and emerin Given that both Dp71d and Dp71f utilize the importin 2/1 system to enter the nucleus, there may be a mechanism that favors nuclear retention of Dp71d but not Dp71f

A reciprocal activation loop exists between microglia and T cells (Xu et al., 2023): M1-polarized microglia secrete IL-6 and IL-1 which, in the presence of transforming growth factor-, promote Th17 differentiation while inhibiting Treg development in nave T cells (Zhang C

Then superoxide binds near copper in the active site, and the copper(I) is oxidized to copper(II), while the superoxide molecule is reduced to hydrogen peroxide