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Research investigating the relationship between Lp(a) and AD has revealed that RA and SLE patients exhibit significantly elevated serum Lp(a) levels [193, 194]

The mRNA and protein levels of the hub genes decrease in a dose-dependent manner in FIN56-treated GC cells, indicating that FIN56 regulates hub gene expression during ferroptosis and suggesting its potential as a drug for inhibiting invasion by GC cells [91]

This process promotes the oligomerization of p62 with Keap1, facilitating the degradation of Keap1 and the subsequent nuclear translocation of Nrf2 via cellular autophagy

doi: 10.1038/s41430-023-01358-9 73

Further pre-clinical and clinical studies are required to identify the optimum scheduling and determine the precise molecular mechanisms underlying metformin mediated radiosensitisation