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Oxidative stress refers to the imbalance between oxidants and antioxidants in organisms, which leads to the accumulation of oxidants in organisms and induces cell damage

2010;8:e1000479 Szilagyi JT, Mishin V, Heck DE, Jan YH, Aleksunes LM, Richardson JR, et al

Direct Evidence for A Role of Redox Dysregulation in Als In this section, we discuss evidence demonstrating that the central cellular redox regulatory mechanisms and associated proteins are perturbed in ALS (Table 2)

As an inhibitor of NRF2, Keap1 recognizes and binds to the ETGE and DLG motifs of NRF2 via its Kelch repeat domain, thereby continuously suppressing and promoting the degradation of NRF2 [87]

10.2174/09298673113209990141 134 ReadA.SchrderM

de L., Levy, D., & Bydlowski, S