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Although erastin demonstrates a potent inhibitory effect on Systems Xc-, its practical application in vivo is significantly hindered by its limited water solubility and metabolic instability

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Di Paola R, Modafferi S, Siracusa R, Cordaro M, D'Amico R, Ontario ML, Interdonato L, Salinaro AT, Fusco R, Impellizzeri D, Calabrese V, Cuzzocrea S

For example, inhibitory factors in the extracellular environment include inhibitory ligands released from the myelin sheath and glial cells after injury, as well as glial scars, and they also include the Nogo transmembrane protein and myelin sheath-related proteins