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[ 359 , 360 ] Treatment with Caffeic Acid Phenethyl Ester (CAPE) and its synthetic analog VP961, known for their ability to modulate NRF2 activity and facilitate NRF2 nuclear translocation, leading to enhanced antioxidant response in Ts2Cje mice (a Down syndrome mouse model) and human Down syndrome lymphoblastoid cell lines (LCLs)

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The major reasons behind the selection of these macromolecules 1JIJ, 2XCT, 1HD2, and 1CX2 are their key role in antibacterial, antioxidant and anti-inflammatory pathways, and they are also commonly targeted in similar studies 21,23

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