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J Neurochem 120(3):461472

Doi: Costa ACS, Brando AC, Boada R, Barrionuevo VL, Taylor HG, Roth E, Stasko MR et al (2022) Safety, Efficacy, and Tolerability of Memantine for Cognitive and Adaptive Outcome Measures in Adolescents and Young Adults with Down Syndrome: A Randomised, Double-Blind, Placebo-Controlled Phase 2 Trial

3 , CD003053 (2003)

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At physiological pH, H 2 S (pKa ~7) exists predominantly (~70%) as the hydrosulfide anion (HS ) while the conjugate acid freely diffuses through biological membranes to access the catabolic machinery within mitochondria 4