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doi: 10.1186/s12916020-01587-w 202 TraberMGStevensJF

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Integrating these research results, GPX4 can be regarded not only as a potential biomarker sensitively reflecting OA pathological severity and disease stage but also as a therapeutically promising target with core protective functions in OA progression

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To a solution of methyl 3-(1-(4-methoxybenzyl)-1H-pyrazol-3-yl)-2-oxopropanoate (9.8 g, 34.0 mmol) in THF (100 mL) was added NaBH 4 (1.929 g, 51.0 mmol) at 0 C