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In one embodiment, the polypeptide sequence of an Fc monomer is substantially similar to an Fc polypeptide sequence of: an Igd Fc region, an lgG 2 Fc region, an lgG 3 Fc region, an lgG 4 Fc region, an IgM Fc region, an IgA Fc region, an IgD Fc region and an IgE Fc region

For example, curcumin inhibits the methylation of lysine 4/9/27 on histone H3 in leukemia cells by inhibiting histone lysine methyltransferase (HKMT) and enhancing the activity of histone lysine demethylase (HKDMT) with consequent changes in gene expression that could contribute to its antitumor effect

Although dramatic mitophagy is not practicable in neurons, evidence of ROS inhibition through mitophagy in a physiological context has been garnered

Alpha-lipoic acid and neuropathy ALA may help reduce the symptoms of peripheral neuropathy, nerve damage that can be caused by diabetes

Kuo WN, Kanadia RN, Shanbhag VP