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Key chemokines CXCL1, CXCL2, and CXCL8 draw neutrophils primarily through the chemokine receptors CXCR1 and CXCR2, which release proteases and ROS, causing hepatocyte necrosis (141)

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Implication of Gut Microbiota in Cardiovascular Diseases

Of note, TNF--induced apoptosis could be mitigated by pretreatment with a generalized PKC inhibitor, suggesting that PKC is an effector by which TNF- promotes apoptosis in reperfusion injury (121)