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Description

This conformational shift impairs the conversion of phosphoenolpyruvate (PEP), leading to the accumulation of glycolytic intermediates that fuel anabolic biosynthesis [96]

In vivo skin insertion and skin motility studies showed that the system delivered approximately 8.5-fold higher concentrations of the drug carvacrol in nanoparticle form compared to a topically applied hydrogel containing pure carvacrol, indicating its potential for increasing the transdermal delivery of nanoparticles using hollow microneedles[60]