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Dopaminergic imaging may also have potential to detect neurodegeneration at premotor stages of PD, although with less sensitivity 21,22 (Table 1), with reduced striatal uptake observed in idiopathic REM sleep behaviour disorder (RBD) 23 and hyposmia 24

Nitric Oxide and Peroxynitrite in Neurodegenerative Disorders NO is produced by all brain cells including neurons, endothelial cells, and glial cells (astrocytes, oligodendrocytes, and microglia) by Ca 2+ /calmodulin-dependent NOS isoforms

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HEK flp-InTm T-RExTM-293 cells (Invitrogen, Darmstadt, Germany) were transfected with this construct using a standard polyethylenimine-based approach

The resulting membrane depolarization then creates an inwardly directed driving force for Cl via anion channels, which in turn causes the additional influx of Na + and K + in order to achieve charge neutralization

doi: 10.1016/j.semcancer.2018.07.009