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As a lot of risk factors of hair loss, like smoking, stress or UV radiation exposure are associated to the damaging effect of reactive oxygen species (ROS) [20] [21], a compromised antioxidant-defence system, due to selenium deficiency, will likely worsen the negative effects of these risk factors

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Senthilnathan P, Padmavathi R, Banu SM, Sakthisekaran D

The dramatic reduction of T4 cellular uptake that occurs with a wide variety of conditions also explains why T4 preparations are often associated with poor clinical response (i.e., continued residual symptoms)