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10.1093/toxsci/kfy143 64 YilmazB

For the vast majority of people, the answer is a resounding yes

In individuals with NOD2 mutations, the gut microbiota exhibits compositional and diversity dysregulation, characterized by a decreased abundance of certain beneficial bacteria and an excessive proliferation of harmful bacteria, which may exacerbate intestinal inflammatory responses

The conjugates, further unexpectedly, can reduce sharply the activity of these conjugates relative to that of the unconjugated pharmaceutical agents in most cell lines of tissue types other than colon, breast, and central nervous system, thereby reducing potential side effects of the conjugates versus those of the unconjugated pharmaceutical agents

Fleckenstein M, Schmitz-Valckenberg S, Chakravarthy U

doi: 10.1177/0363546520968284 15 TanSHSKwanYTNeoWJChongJYKuekTYJSeeJZFet al