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Ghasemi M, Schachter SC

Increased levels of cytoplasmic Ca 2+ can boost TGF-1 signaling mediated by HIF-1

doi pubmed Teramoto A, Yamanaka-Okumura H, Urano E, Nakamura-Kutsuzawa T, Sugihara K, Katayama T, Miyake H, et al

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18 While this did not make a large difference in protein synthesis levels when PEP was used as an energy substrate, it dramatically improved the yields and maintained consistent pH when pyruvate was added (Cytomim system) as the energy substrate instead of PEP

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