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NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1

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The mechanisms of action as per data collected, it is established that the aforementioned medicinal plants referred can modulate the brain signaling pathways responsibly for the symptoms of depression