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10.1097/cad.0b013e3283355227 9 ChengZ.KangC.CheS.SuJ.SunQ.GeT.et al (2022)

Goblet cell hyperplasia, metaplasia, and excessive mucus production are key pathological features of chronic airway diseases such as chronic obstructive bronchitis (part of COPD) and CF

COMMD5 loss leads to excessive autophagy with inefficient degradation, resulting in ROS accumulation, mitochondrial failure, and cell death (184)

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2.3 GABA promotes -cell proliferation and survival Loss of -cell mass due to a reduction in -cell proliferation/regeneration and accelerated -cell apoptosis are synergistic processes leading to the clinical manifestations of TID