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Clinical manifestations include acute pain crises, hemolytic anemia, and multi-organ dysfunction, imposing substantial morbidity and mortality challenges

RESULTS The results showed that there was a significant relationship of serum iron with GST (r=-0.487

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Molecular Biology of the Cell

Quantitative PCR was performed using Power SYBR Green PCR Master Mix and QuantStudio Real-Time PCR system

The prooxidant oxidative stress imbalance needs an antioxidant system able to balance it and the principal role in antioxidant defense is carried out by antioxidant enzymes, with the paramount involvement of small-molecule antioxidant compounds like GSH