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Uncontrolled pain significantly diminishes patient quality of life and can contribute to the development of depressive symptoms, sleep disturbances, and activity-related anxiety

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A low white blood cell count (leukopenia) decreases disease-fighting cells (leukocytes) in the blood

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The proliferation of adherent-invasive Escherichia coli is associated with the occurrence of Crohns disease, and it can promote the hyphae invasion of Candida into intestinal epithelium and lamina propria through the ability to destroy and invade epithelial cells and trigger intestinal inflammation (Zhilu et al., 2021

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