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Neoadjuvant nivolumab (N) or nivolumab plus ipilimumab (NI) for resectable non-small cell lung cancer (NSCLC)

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Thus, the ATP depletion and mitochondrial ROS burst observed upon SLC25A39 knockdown are expected to blunt PI3K/AKT signaling and subsequently inhibit mTORC1, driving the observed cell death