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Since patients who developed EGFR mutant lung adenocarcinomas with acquired resistance to EGFR inhibitor drugs (gefitinib or erlotinib) exhibit increased copy numbers of MET, c-Met-HGF inhibitors are used for lung cancer treatment alone or in combination with other drugs [148]

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4.5 Sigma Niclosamide dissolution and overnight stirring also produces lower solubility material As shown above ( Figure 5 ), the Sigma Niclosamide product readily dissolves and, over a period of 3 hrs, it achieved a niclosamide supernatant concentration of 680uM

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