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This is a quality indicator, not a formulation flaw its presence at application confirms an intact copper-peptide complex is being delivered

Colon-colon anastomosis complicated by the cysteamine-induced colitis Under deep anesthesia the cysteamine (400 mg/kg) was applied through enema (1 ml/rat) at 8 cm proximal to the anus (as described before) (5-7, 9) and 10 minutes thereafter, the colon-colon anastomosis was created 5 cm proximal to anus

It delivers peptide directly to follicular tissue

However, PKC-mediated phosphorylation was found to reduce the Vmax of DAT and enhanced clathrin-mediated DAT internalization

The respiratory control ratio (RCR), a key measure of coupling efficiency (V3/V4), was significantly increased by DSIP at 10 and 10 M concentrations, suggesting tighter coupling between respiration and phosphorylation