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Nuclear translocation and induction of antioxidant enzyme expression was restored in the presence of Euk134, but not in the presence of iron-chelating drugs deferiprone or desferrioxamine, indicating that the molecular defects in FRDA extend beyond the Fenton reactions per se and likely are due partially to impaired antioxidant signaling (Paupe et al., 2009)

Arnett SV, Clark IA: Inflammatory fatigue and sickness behaviour - lessons for the diagnosis and management of chronic fatigue syndrome

doi: 10.1038/s41585020-03624 231 BarberAENortonJPSpivakAMMulveyMA

Copper peptides are involved in cellular signaling and tissue maintenance rather than cardiovascular activation

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