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The ubiquitin proteasome system in glia and its role in neurodegenerative diseases

PROTAC-based approaches have been developed to selectively degrade aggregation-prone proteins, including QC-01-C175 for tau in AD, XL01126 for LRRK2 in PD, and GW5074 for mutant huntingtin in HD

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It supports the transfer of fatty acids to the mitochondria, allowing efficient energy production