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Furthermore, NF-B modulates p53-mediated apoptosis via promoting the polyubiquitylation and degradation of p53

The sub-lining comprises synovial macrophages (SMs), a network of vascular capillaries, and fibrous and adipose tissue [81]

Developing cell-type-specific SIRT1 regulatorsfor example, hepatocyte-targeted molecules using GalNAc ligands or KC-specific nanoparticlesmay allow targeted activation, while selective inhibition in cells such as activated HSCs could also be explored